Pharma & Healthcare
Leptomycin B
- Types
- 1 Milligram · 5 Milligram · 10 Milligram
- Applications
- Experimental Study · Other
5 editions2 January 2026
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Topotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based…
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