APO RESEARCH · REPORT
Inhaled Nitric Oxide
Nitric oxide is a chemical compound in gas form that is sometimes used to treat infants with severe breathing problems associated with narrow blood vessels in the lungs. It works by relaxing smooth muscle to widen (dilate) blood vessels, especially in the lungs. Nitric oxide is usually used together with a breathing machine (ventilator).
Product & engineering
Understand the product.
Nitric oxide is a chemical compound in gas form that is sometimes used to treat infants with severe breathing problems associated with narrow blood vessels in the lungs. It works by relaxing smooth muscle to widen (dilate) blood vessels, especially in the lungs. Nitric oxide is usually used together with a breathing machine (ventilator).
Inhaled nitric oxide (iNO) is recognized as a potent and selective pulmonary vasodilator that does not decrease systemic vascular tone. The therapeutic application of iNO in human was first described in 1990s. INO therapy was effective to improve oxygenation in infants with persistent pulmonary hypertension of the newborn (PPHN). Owing to its selective pulmonary vasodilator effects, iNO therapy is an important treatment for term newborns with hypoxemic respiratory failure due to PPHN. The Food and Drug Administration of the United States of America first approved iNO in 1999 for use as a medical gas to treat hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in term and late preterm neonates. Thereafter, iNO therapy is clinically applied to treat PPHN in term and late preterm neonates without consensus.
Selected research
Industry Research
Inhaled Nitric Oxide Industry Research Report 2026
Market perspective
Nitric oxide is a chemical compound in gas form that is sometimes used to treat infants with severe breathing problems associated with narrow blood vessels in the lungs. It works by relaxing smooth muscle to widen (dilate) blood vessels, especially in the lungs. Nitric oxide is usually used together with a breathing machine (ventilator).
Inhaled nitric oxide (iNO) is recognized as a potent and selective pulmonary vasodilator that does not decrease systemic vascular tone. The therapeutic application of iNO in human was first described in 1990s. INO therapy was effective to improve oxygenation in infants with persistent pulmonary hypertension of the newborn (PPHN). Owing to its selective pulmonary vasodilator effects, iNO therapy is an important treatment for term newborns with hypoxemic respiratory failure due to PPHN. The Food and Drug Administration of the United States of America first approved iNO in 1999 for use as a medical gas to treat hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in term and late preterm neonates. Thereafter, iNO therapy is clinically applied to treat PPHN in term and late preterm neonates without consensus.
Mallinckrodt monopolizes the global Inhaled Nitric Oxide market, holding a share about 65%.
Read the full market overview
North America is the largest market, with a share about 77%, followed by Asia-Pacific and Europe, have a share about 20 percent.
In terms of product, 800 ppm is the largest segment, with a share over 50%. And in terms of application, the largest application is Near-term and Pre-term Infants PPHN, followed by Children and Adult ARDS, etc.
Report Scope
This report quantifies the global Inhaled Nitric Oxide market in terms of revenue (US$ million) and, where applicable, sales volume (M L), using 2025 as the base year and providing annual historical and forecast data for 2021–2032.
It standardizes definitions of Types and Applications, harmonizes vendor attribution, and presents comparable time series by company, Type, Application, and region/country, including indicative price bands (US$/M L) and concentration ratios (CR5/CR10).
The outputs are intended to support strategy development, budgeting, and performance benchmarking for brand owners, manufacturers, retailers, channel partners, and investors; data are structured with consistent units and fields to facilitate integration into internal FP&A and BI systems.
Key Companies & Market Share Insights
This section profiles leading manufacturers, combining 2021–2025 results with a 2026–2032 outlook. It reports revenue, market share, price bands, product and application mix, regional and channel mix, and key developments (M&A, capacity additions, certifications). It also provides global revenue, average price, and—where applicable—sales volume by manufacturer, and calculates CR5/CR10 and rank changes to support comparative benchmarking.
Inhaled Nitric Oxide Market by Company
Mallinckrodt
Praxair (Linde plc)
Air Liquide
BOC Healthcare (Linde Group)
Inhaled Nitric Oxide Segment by Type
800 ppm
100 ppm
Others
Inhaled Nitric Oxide Segment by Application
Near-term and Pre-term Infants PPHN
Children and Adult ARDS
Other Diseases
Inhaled Nitric Oxide Segment by Region
North America
United States
Canada
Mexico
Europe
Germany
France
U.K.
Italy
Russia
Spain
Netherlands
Switzerland
Sweden
Poland
Asia-Pacific
China
Japan
South Korea
India
Australia
Taiwan
Southeast Asia
South America
Brazil
Argentina
Chile
Middle East & Africa
Egypt
South Africa
Israel
Türkiye
GCC Countries
Key Drivers & Barriers
High-impact rendering factors and drivers have been studied in this report to aid the readers to understand the general development. Moreover, the report includes restraints and challenges that may act as stumbling blocks on the way of the players. This will assist the users to be attentive and make informed decisions related to business. Specialists have also laid their focus on the upcoming business prospects.
Reasons to Buy This Report
1. This report will help the readers to understand the competition within the industries and strategies for the competitive environment to enhance the potential profit. The report also focuses on the competitive landscape of the global Inhaled Nitric Oxide market, and introduces in detail the market share, industry ranking, competitor ecosystem, market performance, new product development, operation situation, expansion, and acquisition. etc. of the main players, which helps the readers to identify the main competitors and deeply understand the competition pattern of the market.
2. This report will help stakeholders to understand the global industry status and trends of Inhaled Nitric Oxide and provides them with information on key market drivers, restraints, challenges, and opportunities.
3. This report will help stakeholders to understand competitors better and gain more insights to strengthen their position in their businesses. The competitive landscape section includes the market share and rank (in volume and value), competitor ecosystem, new product development, expansion, and acquisition.
4. This report stays updated with novel technology integration, features, and the latest developments in the market
5. This report helps stakeholders to gain insights into which regions to target globally
6. This report helps stakeholders to gain insights into the end-user perception concerning the adoption of Inhaled Nitric Oxide.
7. This report helps stakeholders to identify some of the key players in the market and understand their valuable contribution.
Chapter Outline
Chapter 1: Research objectives, research methods, data sources, data cross-validation;
Chapter 2: Introduces the report scope of the report, executive summary of different market segments (by region, product type, application, etc.), including the market size of each market segment, future development potential, and so on. It offers a high-level view of the current state of the market and its likely evolution in the short to mid-term, and long term.
Chapter 3: Detailed analysis of Inhaled Nitric Oxide manufacturers competitive landscape, price, production and value market share, latest development plan, merger, and acquisition information, etc.
Chapter 4: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product production/output, value, price, gross margin, product introduction, recent development, etc.
Chapter 5: Production/output, value of Inhaled Nitric Oxide by region/country. It provides a quantitative analysis of the market size and development potential of each region in the next six years.
Chapter 6: Consumption of Inhaled Nitric Oxide in regional level and country level. It provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space, and production of each country in the world.
Chapter 7: Provides the analysis of various market segments by type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 8: Provides the analysis of various market segments by application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 9: Analysis of industrial chain, including the upstream and downstream of the industry.
Chapter 10: Introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 11: The main points and conclusions of the report.
More report detail
Tables and figures
Scope & coverage.
Types
- 800 ppm
- 100 ppm
- Others
Applications
- Near-term and Pre-term Infants PPHN
- Children and Adult ARDS
- Other Diseases
Companies covered
- Mallinckrodt
- Praxair (Linde plc)
- Air Liquide
- BOC Healthcare (Linde Group)
Inside the report.
1 Preface
- 1.1 Scope of Report
- 1.2 Reasons for Doing This Study
- 1.3 Research Methodology
- 1.4 Research Process
- 1.5 Data Source
- 1.5.1 Secondary Sources
- 1.5.2 Primary Sources
2 Market Overview
- 2.1 Product Definition
- 2.2 Global Market Growth Prospects
- 2.2.1 Global Inhaled Nitric Oxide Market Size (2021-2032)
- 2.2.2 Global Inhaled Nitric Oxide Sales (2021-2032)
- 2.2.3 Global Inhaled Nitric Oxide Market Average Price (2021-2032)
- 2.3 Inhaled Nitric Oxide by Type
- 2.3.1 Market Value Comparison by Type (2021 VS 2025 VS 2032) & (US$ Million)
- 2.3.2 800 ppm
- 2.3.3 100 ppm
- 2.3.4 Others
- 2.4 Inhaled Nitric Oxide by Application
- 2.4.1 Market Value Comparison by Application (2021 VS 2025 VS 2032)
- 2.4.2 Near-term and Pre-term Infants PPHN
- 2.4.3 Children and Adult ARDS
- 2.4.4 Other Diseases
3 Market Competitive Landscape by Manufacturers
- 3.1 Global Inhaled Nitric Oxide Market Competitive Situation by Manufacturers (2021 Versus 2025)
- 3.2 Global Inhaled Nitric Oxide Sales (M L) of Manufacturers (2021-2026)
- 3.3 Global Inhaled Nitric Oxide Revenue of Manufacturers (2021-2026)
- 3.4 Global Inhaled Nitric Oxide Average Price by Manufacturers (2021-2026)
- 3.5 Global Inhaled Nitric Oxide Industry Ranking, 2024 VS 2025 VS 2026
- 3.6 Global Manufacturers of Inhaled Nitric Oxide, Manufacturing Sites & Headquarters
- 3.7 Global Manufacturers of Inhaled Nitric Oxide, Product Type & Application
- 3.8 Global Manufacturers of Inhaled Nitric Oxide, Established Date
- 3.9 Global Inhaled Nitric Oxide Market CR5 and HHI
- 3.10 Global Manufacturers Mergers & Acquisition
4 Manufacturers Profiled
- 4.1 Mallinckrodt
- 4.1.1 Mallinckrodt Company Information
- 4.1.2 Mallinckrodt Business Overview
- 4.1.3 Mallinckrodt Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 4.1.4 Mallinckrodt Inhaled Nitric Oxide Product Portfolio
- 4.1.5 Mallinckrodt Recent Developments
- 4.2 Praxair (Linde plc)
- 4.2.1 Praxair (Linde plc) Company Information
- 4.2.2 Praxair (Linde plc) Business Overview
- 4.2.3 Praxair (Linde plc) Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 4.2.4 Praxair (Linde plc) Inhaled Nitric Oxide Product Portfolio
- 4.2.5 Praxair (Linde plc) Recent Developments
- 4.3 Air Liquide
- 4.3.1 Air Liquide Company Information
- 4.3.2 Air Liquide Business Overview
- 4.3.3 Air Liquide Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 4.3.4 Air Liquide Inhaled Nitric Oxide Product Portfolio
- 4.3.5 Air Liquide Recent Developments
- 4.4 BOC Healthcare (Linde Group)
- 4.4.1 BOC Healthcare (Linde Group) Company Information
- 4.4.2 BOC Healthcare (Linde Group) Business Overview
- 4.4.3 BOC Healthcare (Linde Group) Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 4.4.4 BOC Healthcare (Linde Group) Inhaled Nitric Oxide Product Portfolio
- 4.4.5 BOC Healthcare (Linde Group) Recent Developments
5 Global Inhaled Nitric Oxide Market Scenario by Region
- 5.1 Global Inhaled Nitric Oxide Market Size by Region: 2021 VS 2025 VS 2032
- 5.2 Global Inhaled Nitric Oxide Sales by Region: 2021-2032
- 5.2.1 Global Inhaled Nitric Oxide Sales by Region: 2021-2026
- 5.2.2 Global Inhaled Nitric Oxide Sales by Region: 2027-2032
- 5.3 Global Inhaled Nitric Oxide Revenue by Region: 2021-2032
- 5.3.1 Global Inhaled Nitric Oxide Revenue by Region: 2021-2026
- 5.3.2 Global Inhaled Nitric Oxide Revenue by Region: 2027-2032
- 5.4 North America Inhaled Nitric Oxide Market Facts & Figures by Country
- 5.4.1 North America Inhaled Nitric Oxide Market Size by Country: 2021 VS 2025 VS 2032
- 5.4.2 North America Inhaled Nitric Oxide Sales by Country (2021-2032)
- 5.4.3 North America Inhaled Nitric Oxide Revenue by Country (2021-2032)
- 5.4.4 United States
- 5.4.5 Canada
- 5.4.6 Mexico
- 5.5 Europe Inhaled Nitric Oxide Market Facts & Figures by Country
- 5.5.1 Europe Inhaled Nitric Oxide Market Size by Country: 2021 VS 2025 VS 2032
- 5.5.2 Europe Inhaled Nitric Oxide Sales by Country (2021-2032)
- 5.5.3 Europe Inhaled Nitric Oxide Revenue by Country (2021-2032)
- 5.5.4 Germany
- 5.5.5 France
- 5.5.6 U.K.
- 5.5.7 Italy
- 5.5.8 Russia
- 5.5.9 Spain
- 5.5.10 Netherlands
- 5.5.11 Switzerland
- 5.5.12 Sweden
- 5.5.13 Poland
- 5.6 Asia Pacific Inhaled Nitric Oxide Market Facts & Figures by Country
- 5.6.1 Asia Pacific Inhaled Nitric Oxide Market Size by Country: 2021 VS 2025 VS 2032
- 5.6.2 Asia Pacific Inhaled Nitric Oxide Sales by Country (2021-2032)
- 5.6.3 Asia Pacific Inhaled Nitric Oxide Revenue by Country (2021-2032)
- 5.6.4 China
- 5.6.5 Japan
- 5.6.6 South Korea
- 5.6.7 India
- 5.6.8 Australia
- 5.6.9 Taiwan
- 5.6.10 Southeast Asia
- 5.7 South America Inhaled Nitric Oxide Market Facts & Figures by Country
- 5.7.1 South America Inhaled Nitric Oxide Market Size by Country: 2021 VS 2025 VS 2032
- 5.7.2 South America Inhaled Nitric Oxide Sales by Country (2021-2032)
- 5.7.3 South America Inhaled Nitric Oxide Revenue by Country (2021-2032)
- 5.7.4 Brazil
- 5.7.5 Argentina
- 5.7.6 Chile
- 5.8 Middle East and Africa Inhaled Nitric Oxide Market Facts & Figures by Country
- 5.8.1 Middle East and Africa Inhaled Nitric Oxide Market Size by Country: 2021 VS 2025 VS 2032
- 5.8.2 Middle East and Africa Inhaled Nitric Oxide Sales by Country (2021-2032)
- 5.8.3 Middle East and Africa Inhaled Nitric Oxide Revenue by Country (2021-2032)
- 5.8.4 Egypt
- 5.8.5 South Africa
- 5.8.6 Israel
- 5.8.7 Türkiye
- 5.8.8 GCC Countries
6 Segment by Type
- 6.1 Global Inhaled Nitric Oxide Sales by Type (2021-2032)
- 6.1.1 Global Inhaled Nitric Oxide Sales by Type (2021-2032) & (M L)
- 6.1.2 Global Inhaled Nitric Oxide Sales Market Share by Type (2021-2032)
- 6.2 Global Inhaled Nitric Oxide Revenue by Type (2021-2032)
- 6.2.1 Global Inhaled Nitric Oxide Sales by Type (2021-2032) & (US$ Million)
- 6.2.2 Global Inhaled Nitric Oxide Revenue Market Share by Type (2021-2032)
- 6.3 Global Inhaled Nitric Oxide Price by Type (2021-2032)
7 Segment by Application
- 7.1 Global Inhaled Nitric Oxide Sales by Application (2021-2032)
- 7.1.1 Global Inhaled Nitric Oxide Sales by Application (2021-2032) & (M L)
- 7.1.2 Global Inhaled Nitric Oxide Sales Market Share by Application (2021-2032)
- 7.2 Global Inhaled Nitric Oxide Revenue by Application (2021-2032)
- 7.2.1 Global Inhaled Nitric Oxide Sales by Application (2021-2032) & (US$ Million)
- 7.2.2 Global Inhaled Nitric Oxide Revenue Market Share by Application (2021-2032)
- 7.3 Global Inhaled Nitric Oxide Price by Application (2021-2032)
8 Value Chain and Sales Channels Analysis of the Market
- 8.1 Inhaled Nitric Oxide Value Chain Analysis
- 8.1.1 Inhaled Nitric Oxide Key Raw Materials
- 8.1.2 Raw Materials Key Suppliers
- 8.1.3 Inhaled Nitric Oxide Production Mode & Process
- 8.2 Inhaled Nitric Oxide Sales Channels Analysis
- 8.2.1 Direct Comparison with Distribution Share
- 8.2.2 Inhaled Nitric Oxide Distributors
- 8.2.3 Inhaled Nitric Oxide Customers
9 Global Inhaled Nitric Oxide Analyzing Market Dynamics
- 9.1 Inhaled Nitric Oxide Industry Trends
- 9.2 Inhaled Nitric Oxide Industry Drivers
- 9.3 Inhaled Nitric Oxide Industry Opportunities and Challenges
- 9.4 Inhaled Nitric Oxide Industry Restraints
10 Report Conclusion
11 Disclaimer
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