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Inhaled Nitric Oxide
Nitric oxide is a chemical compound in gas form that is sometimes used to treat infants with severe breathing problems associated with narrow blood vessels in the lungs. It works by relaxing smooth muscle to widen (dilate) blood vessels, especially in the lungs. Nitric oxide is usually used together with a breathing machine (ventilator).
Product & engineering
Understand the product.
Nitric oxide is a chemical compound in gas form that is sometimes used to treat infants with severe breathing problems associated with narrow blood vessels in the lungs. It works by relaxing smooth muscle to widen (dilate) blood vessels, especially in the lungs. Nitric oxide is usually used together with a breathing machine (ventilator).
Inhaled nitric oxide (iNO) is recognized as a potent and selective pulmonary vasodilator that does not decrease systemic vascular tone. The therapeutic application of iNO in human was first described in 1990s. INO therapy was effective to improve oxygenation in infants with persistent pulmonary hypertension of the newborn (PPHN). Owing to its selective pulmonary vasodilator effects, iNO therapy is an important treatment for term newborns with hypoxemic respiratory failure due to PPHN. The Food and Drug Administration of the United States of America first approved iNO in 1999 for use as a medical gas to treat hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in term and late preterm neonates. Thereafter, iNO therapy is clinically applied to treat PPHN in term and late preterm neonates without consensus.
Selected research
Industry Growth & Trends
Global Inhaled Nitric Oxide Industry Growth and Trends Forecast to 2032
Market perspective
Nitric oxide is a chemical compound in gas form that is sometimes used to treat infants with severe breathing problems associated with narrow blood vessels in the lungs. It works by relaxing smooth muscle to widen (dilate) blood vessels, especially in the lungs. Nitric oxide is usually used together with a breathing machine (ventilator).
Inhaled nitric oxide (iNO) is recognized as a potent and selective pulmonary vasodilator that does not decrease systemic vascular tone. The therapeutic application of iNO in human was first described in 1990s. INO therapy was effective to improve oxygenation in infants with persistent pulmonary hypertension of the newborn (PPHN). Owing to its selective pulmonary vasodilator effects, iNO therapy is an important treatment for term newborns with hypoxemic respiratory failure due to PPHN. The Food and Drug Administration of the United States of America first approved iNO in 1999 for use as a medical gas to treat hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in term and late preterm neonates. Thereafter, iNO therapy is clinically applied to treat PPHN in term and late preterm neonates without consensus.
Mallinckrodt monopolizes the global Inhaled Nitric Oxide market, holding a share about 65%.
Read the full market overview
North America is the largest market, with a share about 77%, followed by Asia-Pacific and Europe, have a share about 20 percent.
In terms of product, 800 ppm is the largest segment, with a share over 50%. And in terms of application, the largest application is Near-term and Pre-term Infants PPHN, followed by Children and Adult ARDS, etc.
Report Scope
This report provides a structured, data-driven view of the global Inhaled Nitric Oxide market, combining harmonized quantitative metrics with targeted qualitative insight to support business and growth strategy, market positioning, and capital allocation.
The Inhaled Nitric Oxide market size, estimates, and forecasts are presented in terms of sales volume (M L) and revenue (US$ million), with 2025 as the base year and historical and forecast data for 2021-2032. The report segments the global Inhaled Nitric Oxide market by Type, Application, region/country, and company, provides regional market sizes at the segment level, profiles the competitive landscape and key players and their market ranks, and reviews technology trends and new product developments relevant to Inhaled Nitric Oxide.
Key Companies & Market Share Insights
This section analyzes the strategies and performance of leading manufacturers in the global Inhaled Nitric Oxide market, including portfolio focus, innovation and product development, mergers and acquisitions, collaborations, and geographic expansion used to sustain or enhance competitive positions. It also summarizes recent corporate developments and key financial indicators and provides global revenue, price, and sales volume data by manufacturer for 2020-2025, enabling benchmarking of scale, pricing, and market share and supporting assessment of market concentration through indicators such as CR5 and CR10.
Inhaled Nitric Oxide Market by Company
Mallinckrodt
Praxair (Linde plc)
Air Liquide
BOC Healthcare (Linde Group)
Inhaled Nitric Oxide Segment by Type
800 ppm
100 ppm
Others
Inhaled Nitric Oxide Segment by Application
Near-term and Pre-term Infants PPHN
Children and Adult ARDS
Other Diseases
Inhaled Nitric Oxide Segment by Region
North America
United States
Canada
Mexico
Europe
Germany
France
U.K.
Italy
Russia
Spain
Netherlands
Switzerland
Sweden
Poland
Asia-Pacific
China
Japan
South Korea
India
Australia
Taiwan
Southeast Asia
South America
Brazil
Argentina
Chile
Middle East & Africa
Egypt
South Africa
Israel
Türkiye
GCC Countries
Key Drivers & Barriers
High-impact rendering factors and drivers have been studied in this report to aid the readers to understand the general development. Moreover, the report includes restraints and challenges that may act as stumbling blocks on the way of the players. This will assist the users to be attentive and make informed decisions related to business. Specialists have also laid their focus on the upcoming business prospects.
Reasons to Buy This Report
1. This report will help the readers to understand the competition within the industries and strategies for the competitive environment to enhance the potential profit. The report also focuses on the competitive landscape of the global Inhaled Nitric Oxide market, and introduces in detail the market share, industry ranking, competitor ecosystem, market performance, new product development, operation situation, expansion, and acquisition. etc. of the main players, which helps the readers to identify the main competitors and deeply understand the competition pattern of the market.
2. This report will help stakeholders to understand the global industry status and trends of Inhaled Nitric Oxide and provides them with information on key market drivers, restraints, challenges, and opportunities.
3. This report will help stakeholders to understand competitors better and gain more insights to strengthen their position in their businesses. The competitive landscape section includes the market share and rank (in volume and value), competitor ecosystem, new product development, expansion, and acquisition.
4. This report stays updated with novel technology integration, features, and the latest developments in the market.
5. This report helps stakeholders to gain insights into which regions to target globally.
6. This report helps stakeholders to gain insights into the end-user perception concerning the adoption of Inhaled Nitric Oxide.
7. This report helps stakeholders to identify some of the key players in the market and understand their valuable contribution.
Chapter Outline
Chapter 1: Introduces the study scope of this report, executive summary of market segments by type, market size segments for North America, Europe, Asia Pacific, South America, Middle East & Africa.
Chapter 2: Introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 3: Detailed analysis of Inhaled Nitric Oxide manufacturers competitive landscape, price, sales, revenue, market share and ranking, latest development plan, merger, and acquisition information, etc.
Chapter 4: Sales, revenue of Inhaled Nitric Oxide in regional level. It provides a quantitative analysis of the market size and development potential of each region and introduces the future development prospects, and market space in the world.
Chapter 5: Introduces market segments by application, market size segment for North America, Europe, Asia Pacific, South America, Middle East & Africa.
Chapter 6: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product sales, revenue, price, gross margin, product introduction, recent development, etc.
Chapter 7, 8, 9, 10 and 11: North America, Europe, Asia Pacific, South America, Middle East & Africa, sales and revenue by country.
Chapter 12: Analysis of industrial chain, key raw materials, manufacturing cost, and market dynamics.
Chapter 13: Concluding Insights of the report.
More report detail
Tables and figures
Scope & coverage.
Types
- 800 ppm
- 100 ppm
- Others
Applications
- Near-term and Pre-term Infants PPHN
- Children and Adult ARDS
- Other Diseases
Companies covered
- Mallinckrodt
- Praxair (Linde plc)
- Air Liquide
- BOC Healthcare (Linde Group)
Inside the report.
1 Market Overview
- 1.1 Product Definition
- 1.2 Global Market Growth Prospects
- 1.2.1 Global Inhaled Nitric Oxide Market Size Estimates and Forecasts (2021-2032)
- 1.2.2 Global Inhaled Nitric Oxide Sales Estimates and Forecasts (2021-2032)
- 1.3 Inhaled Nitric Oxide Market by Type
- 1.3.1 800 ppm
- 1.3.2 100 ppm
- 1.3.3 Others
- 1.4 Global Inhaled Nitric Oxide Market Size by Type
- 1.4.1 Global Inhaled Nitric Oxide Market Size Overview by Type (2021-2032)
- 1.4.2 Global Inhaled Nitric Oxide Historic Market Size Review by Type (2021-2026)
- 1.4.3 Global Inhaled Nitric Oxide Forecasted Market Size by Type (2027-2032)
- 1.5 Key Regions Market Size by Type
- 1.5.1 North America Inhaled Nitric Oxide Sales Breakdown by Type (2021-2026)
- 1.5.2 Europe Inhaled Nitric Oxide Sales Breakdown by Type (2021-2026)
- 1.5.3 Asia-Pacific Inhaled Nitric Oxide Sales Breakdown by Type (2021-2026)
- 1.5.4 South America Inhaled Nitric Oxide Sales Breakdown by Type (2021-2026)
- 1.5.5 Middle East and Africa Inhaled Nitric Oxide Sales Breakdown by Type (2021-2026)
2 Global Market Dynamics
- 2.1 Inhaled Nitric Oxide Industry Trends
- 2.2 Inhaled Nitric Oxide Industry Drivers
- 2.3 Inhaled Nitric Oxide Industry Opportunities and Challenges
- 2.4 Inhaled Nitric Oxide Industry Restraints
3 Market Competitive Landscape by Company
- 3.1 Global Top Players by Inhaled Nitric Oxide Revenue (2021-2026)
- 3.2 Global Top Players by Inhaled Nitric Oxide Sales (2021-2026)
- 3.3 Global Top Players by Inhaled Nitric Oxide Price (2021-2026)
- 3.4 Global Inhaled Nitric Oxide Industry Company Ranking, 2024 VS 2025 VS 2026
- 3.5 Global Inhaled Nitric Oxide Major Company Production Sites & Headquarters
- 3.6 Global Inhaled Nitric Oxide Company, Product Type & Application
- 3.7 Global Inhaled Nitric Oxide Company Establishment Date
- 3.8 Market Competitive Analysis
- 3.8.1 Global Inhaled Nitric Oxide Market CR5 and HHI
- 3.8.2 Global Top 5 and 10 Inhaled Nitric Oxide Players Market Share by Revenue in 2025
- 3.8.3 2025 Inhaled Nitric Oxide Tier 1, Tier 2, and Tier 3
4 Inhaled Nitric Oxide Regional Status and Outlook
- 4.1 Global Inhaled Nitric Oxide Market Size and CAGR by Region: 2021 VS 2025 VS 2032
- 4.2 Global Inhaled Nitric Oxide Historic Market Size by Region
- 4.2.1 Global Inhaled Nitric Oxide Sales in Volume by Region (2021-2026)
- 4.2.2 Global Inhaled Nitric Oxide Sales in Value by Region (2021-2026)
- 4.2.3 Global Inhaled Nitric Oxide Sales (Volume & Value), Price and Gross Margin (2021-2026)
- 4.3 Global Inhaled Nitric Oxide Forecasted Market Size by Region
- 4.3.1 Global Inhaled Nitric Oxide Sales in Volume by Region (2027-2032)
- 4.3.2 Global Inhaled Nitric Oxide Sales in Value by Region (2027-2032)
- 4.3.3 Global Inhaled Nitric Oxide Sales (Volume & Value), Price and Gross Margin (2027-2032)
5 Inhaled Nitric Oxide by Application
- 5.1 Inhaled Nitric Oxide Market by Application
- 5.1.1 Near-term and Pre-term Infants PPHN
- 5.1.2 Children and Adult ARDS
- 5.1.3 Other Diseases
- 5.2 Global Inhaled Nitric Oxide Market Size by Application
- 5.2.1 Global Inhaled Nitric Oxide Market Size Overview by Application (2021-2032)
- 5.2.2 Global Inhaled Nitric Oxide Historic Market Size Review by Application (2021-2026)
- 5.2.3 Global Inhaled Nitric Oxide Forecasted Market Size by Application (2027-2032)
- 5.3 Key Regions Market Size by Application
- 5.3.1 North America Inhaled Nitric Oxide Sales Breakdown by Application (2021-2026)
- 5.3.2 Europe Inhaled Nitric Oxide Sales Breakdown by Application (2021-2026)
- 5.3.3 Asia-Pacific Inhaled Nitric Oxide Sales Breakdown by Application (2021-2026)
- 5.3.4 South America Inhaled Nitric Oxide Sales Breakdown by Application (2021-2026)
- 5.3.5 Middle East and Africa Inhaled Nitric Oxide Sales Breakdown by Application (2021-2026)
6 Company Profiles
- 6.1 Mallinckrodt
- 6.1.1 Mallinckrodt Company Information
- 6.1.2 Mallinckrodt Business Overview
- 6.1.3 Mallinckrodt Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 6.1.4 Mallinckrodt Inhaled Nitric Oxide Product Portfolio
- 6.1.5 Mallinckrodt Recent Developments
- 6.2 Praxair (Linde plc)
- 6.2.1 Praxair (Linde plc) Company Information
- 6.2.2 Praxair (Linde plc) Business Overview
- 6.2.3 Praxair (Linde plc) Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 6.2.4 Praxair (Linde plc) Inhaled Nitric Oxide Product Portfolio
- 6.2.5 Praxair (Linde plc) Recent Developments
- 6.3 Air Liquide
- 6.3.1 Air Liquide Company Information
- 6.3.2 Air Liquide Business Overview
- 6.3.3 Air Liquide Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 6.3.4 Air Liquide Inhaled Nitric Oxide Product Portfolio
- 6.3.5 Air Liquide Recent Developments
- 6.4 BOC Healthcare (Linde Group)
- 6.4.1 BOC Healthcare (Linde Group) Company Information
- 6.4.2 BOC Healthcare (Linde Group) Business Overview
- 6.4.3 BOC Healthcare (Linde Group) Inhaled Nitric Oxide Sales, Revenue and Gross Margin (2021-2026)
- 6.4.4 BOC Healthcare (Linde Group) Inhaled Nitric Oxide Product Portfolio
- 6.4.5 BOC Healthcare (Linde Group) Recent Developments
7 North America by Country
- 7.1 North America Inhaled Nitric Oxide Sales by Country
- 7.1.1 North America Inhaled Nitric Oxide Sales Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 7.1.2 North America Inhaled Nitric Oxide Sales by Country (2021-2026)
- 7.1.3 North America Inhaled Nitric Oxide Sales Forecast by Country (2027-2032)
- 7.2 North America Inhaled Nitric Oxide Market Size by Country
- 7.2.1 North America Inhaled Nitric Oxide Market Size Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 7.2.2 North America Inhaled Nitric Oxide Market Size by Country (2021-2026)
- 7.2.3 North America Inhaled Nitric Oxide Market Size Forecast by Country (2027-2032)
8 Europe by Country
- 8.1 Europe Inhaled Nitric Oxide Sales by Country
- 8.1.1 Europe Inhaled Nitric Oxide Sales Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 8.1.2 Europe Inhaled Nitric Oxide Sales by Country (2021-2026)
- 8.1.3 Europe Inhaled Nitric Oxide Sales Forecast by Country (2027-2032)
- 8.2 Europe Inhaled Nitric Oxide Market Size by Country
- 8.2.1 Europe Inhaled Nitric Oxide Market Size Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 8.2.2 Europe Inhaled Nitric Oxide Market Size by Country (2021-2026)
- 8.2.3 Europe Inhaled Nitric Oxide Market Size Forecast by Country (2027-2032)
9 Asia-Pacific by Country
- 9.1 Asia-Pacific Inhaled Nitric Oxide Sales by Country
- 9.1.1 Asia-Pacific Inhaled Nitric Oxide Sales Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 9.1.2 Asia-Pacific Inhaled Nitric Oxide Sales by Country (2021-2026)
- 9.1.3 Asia-Pacific Inhaled Nitric Oxide Sales Forecast by Country (2027-2032)
- 9.2 Asia-Pacific Inhaled Nitric Oxide Market Size by Country
- 9.2.1 Asia-Pacific Inhaled Nitric Oxide Market Size Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 9.2.2 Asia-Pacific Inhaled Nitric Oxide Market Size by Country (2021-2026)
- 9.2.3 Asia-Pacific Inhaled Nitric Oxide Market Size Forecast by Country (2027-2032)
10 South America by Country
- 10.1 South America Inhaled Nitric Oxide Sales by Country
- 10.1.1 South America Inhaled Nitric Oxide Sales Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 10.1.2 South America Inhaled Nitric Oxide Sales by Country (2021-2026)
- 10.1.3 South America Inhaled Nitric Oxide Sales Forecast by Country (2027-2032)
- 10.2 South America Inhaled Nitric Oxide Market Size by Country
- 10.2.1 South America Inhaled Nitric Oxide Market Size Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 10.2.2 South America Inhaled Nitric Oxide Market Size by Country (2021-2026)
- 10.2.3 South America Inhaled Nitric Oxide Market Size Forecast by Country (2027-2032)
11 Middle East and Africa by Country
- 11.1 Middle East and Africa Inhaled Nitric Oxide Sales by Country
- 11.1.1 Middle East and Africa Inhaled Nitric Oxide Sales Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 11.1.2 Middle East and Africa Inhaled Nitric Oxide Sales by Country (2021-2026)
- 11.1.3 Middle East and Africa Inhaled Nitric Oxide Sales Forecast by Country (2027-2032)
- 11.2 Middle East and Africa Inhaled Nitric Oxide Market Size by Country
- 11.2.1 Middle East and Africa Inhaled Nitric Oxide Market Size Growth Rate (CAGR) by Country: 2021 VS 2025 VS 2032
- 11.2.2 Middle East and Africa Inhaled Nitric Oxide Market Size by Country (2021-2026)
- 11.2.3 Middle East and Africa Inhaled Nitric Oxide Market Size Forecast by Country (2027-2032)
12 Value Chain and Sales Channels Analysis
- 12.1 Inhaled Nitric Oxide Value Chain Analysis
- 12.1.1 Inhaled Nitric Oxide Key Raw Materials
- 12.1.2 Key Raw Materials Price
- 12.1.3 Raw Materials Key Suppliers
- 12.1.4 Manufacturing Cost Structure
- 12.1.5 Inhaled Nitric Oxide Production Mode & Process
- 12.2 Inhaled Nitric Oxide Sales Channels Analysis
- 12.2.1 Direct Comparison with Distribution Share
- 12.2.2 Inhaled Nitric Oxide Distributors
- 12.2.3 Inhaled Nitric Oxide Customers
13 Concluding Insights
14 Appendix
- 14.1 Reasons for Doing This Study
- 14.2 Research Methodology
- 14.3 Research Process
- 14.4 Authors List of This Report
- 14.5 Data Source
- 14.5.1 Secondary Sources
- 14.5.2 Primary Sources
- 14.6 Disclaimer
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