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Botulinum toxin is the bacterial toxin secreted by the deadly botulinum toxin, action on the end of the cholinergic nerve, antagonism calcium ion, interference acetylcholine release, make muscle fiber cannot contract cause muscle relaxation, achieve the purpose of wrinkle beauty.Botox was first used as a biological weapon, and was later used by the medical community to treat facial cramps and other muscle-movement disorders. In the 1980s, the plastic surgery community expanded its function, using it to thin the face and shape the legs.China is the third country after the United Kingdom and the United States to produce its own botox cosmetic products, and began to use in 1999.In recent years, global botulinum toxin type A has developed rapidly, with an average growth rate of about 15%. In 2017, global production of botulinum toxin type A was 22.35 million bottles, with an output value of $4 billion.The price of botulinum toxin type A has been on A downward trend due to the economic environment, the improvement of people's health level and the influx of low-end products into the market, with the price dropping from $194 / bottle in 2013 to $178 / bottle in 2017.We expect prices to continue to fall over the next few years as domestic players get bigger and stronger and new products emerge.There are three main types of botulinum toxin A products: 50 units, 100 units and others.Of these, 50 units accounted for the largest share, accounting for 59% of the market in 2017.Botulinum toxin A is used mainly for medical and cosmetic purposes.Medical use accounted for the majority, accounting for about 51% of the total market in 2017.The United States is the top sales region, accounting for 54 percent of global sales in 2017.In 2017, China accounted for 5 percent of global production, while China accounted for 9 percent of global sales. China is an importer.North America is also a major consumer region, but due to the high development level in these regions, the annual growth rate is relatively flat. Currently, there are only two kinds of botox approved in China, namely the balance of lanzhou institute of biological products and the protection of allergan, which have not changed in recent years.Due to the larger dispersion, it is suitable for the injection of larger muscles and itself, such as thin face, thin leg, and the cost of weight is cheap, cost-effective;However, the dispersivity of propofol is small, which is suitable for accurate injection such as wrinkle removal.At present, allergan, ipson, Merz Pharmaceuticals, Medytox, lanzhou hengli and other industrial giants represented by the products occupy the mainstream position in the international market.
