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Aptamers are high affinity molecules that are derived from RNA or DNA. These are normally generated using a synthetic process called “Systematic evolution of ligands by exponential enrichment” (SELEX). Aptamers receive their name from the Latin word aptus meaning “fit”. This means they bind to the target molecules with high specificity and high affinity. Aptamers are short nucleic acids that interact with a variety of targets with high affinity and specificity. They have been shown to inhibit biological functions of cognate target proteins, and they are identifiable by an in vitro selection process, also termed SELEX (Systematic Evolution of Ligands by EXponential enrichment). Being nucleic acids, aptamers can be synthesized chemically or enzymatically.
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