From ticks to the market: A new $210 million cycle for veterinary Lyme disease vaccines.

According to APO Research, the global veterinary Lyme vaccines market reached USD 147.1 million in 2024 on 6.42 million doses and is projected to reach USD 210.6 million by 2031 on 8.42 million doses (2025–2031 CAGR 5.6%, volume-led with moderating ASPs). North America supplied 88.2% of 2024 revenue and remains the growth anchor to USD 188.7 million by 2031, while Europe advances to USD 20.4 million. Recombinant subunits increase their revenue mix from 54.5% to 57.8% by 2031 as practices standardize clear claims and annual revaccination; bacterins persist in price-sensitive channels. Vendor concentration remains high: Zoetis + Boehringer Ingelheim + Elanco ≈ 83.5% of revenue in 2024, followed by Merck Animal Health and Bioveta.

Veterinary Lyme disease vaccines are companion-animal biologics used to reduce the probability and magnitude of infection with Borrelia burgdorferi sensu lato after exposure to competent Ixodes ticks. Clinical use is functionally canine; feline products exist only at marginal scale. Vaccination is risk-based and paired with acaricides and environmental tick management. Lyme-borreliae are host-adapted spirochetes maintained in enzootic cycles linking small mammals and certain birds with hard ticks; larvae and nymphs acquire organisms during a blood meal, retain them transstadially, and transmit during subsequent feedings. Upon tick attachment, vector-adapted gene programs down-shift while mammalian-phase genes up-regulate to enable migration from the midgut to salivary glands. Geographies mirror vector belts: I. scapularis (Northeast/Upper Midwest US), I. pacificus (US West Coast), I. ricinus (Europe), and I. persulcatus (northern Eurasia). North American canine disease is dominated by B. burgdorferi sensu stricto; B. garinii and B. afzelii contribute in Europe and the UK.

From a market and regulatory standpoint, only North America and Europe provide contiguous Ixodes ranges, clear biologics pathways, and stable clinical demand—conditions required for licensed products and defensible sizing. Accordingly, this report quantifies these two regions and treats Asia, South America, and Africa qualitatively to avoid over-extrapolating from heterogeneous, low-signal data.

Market size and drivers. The global Veterinary Lyme Disease Vaccines market was USD147.12 million in 2024, rising from USD116.65 million in 2020 (CAGR 5.97%). It is projected to reach USD210.61 million by 2031 (2025–2031 CAGR 5.57%), driven by volume growth (global doses 6.42→8.42 million, 2020→2031; 2025–2031 CAGR 3.79%) while price growth moderates (ASP USD22.92/dose in 2024 easing to USD22.60 in 2025, then trending toward USD25.02 by 2031). Mix shift favors recombinant subunit vaccines, which accounted for USD80.24 million (54.5%) of 2024 revenue and are expected to reach USD121.71 million (57.8%) by 2031; bacterins remain relevant in price-sensitive channels.

Regional structure. North America represented USD129.68 million (88.15%) in 2024 and is forecast to USD188.72 million by 2031 (CAGR 5.83%), sustained by high I. scapularis/pacificus prevalence, established canine vaccination norms, and specialty distribution. Europe was USD16.35 million (11.11%) in 2024, projected to USD20.39 million by 2031 (CAGR 3.34%); demand is concentrated in Poland, Germany, France, Sweden, Finland, the UK, and Romania, consistent with I. ricinus/persulcatus belts.

Competitor landscape. Based on 2024 reported volumes and realized ASPs, the leading manufacturers are Zoetis (USD50.32m), Boehringer Ingelheim (USD46.02m), Elanco (USD26.44m), Merck Animal Health (USD20.95m), and Bioveta (USD3.39m). The top three account for ~83.5% of global revenue, reflecting scale advantages in R&D, licensure, and North American commercial reach.